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AG Stein

Mikroskop6Welcome to Stein lab website

We belong to the Instiute of Physiology II at the Medical School of the University of Bonn.
Our group was established in spring 2011.

Research overview

The main focus of our work is on the function and development of glutamatergic synapses. We try to decipher the molecular interactions of proteins within the postsynapse and proteins bridging the synaptic cleft. All these processes are linked to the ability of the brain to adapt to an ever changing environment.

In recent years many proteins interacting directly with glutamate receptors haven been discoveres. These interactions partners are critical to maintain the number of receptors in the synapse and are important regulators of the receptor function. Here we study for TARP proteins that directly interact with AMPA type glutamate receptors. TARP proteins modulate the function of AMPA receptors and allow the binging via a PDZ domain to PSD-95. PSD-95 is a scaffolding molecule regulating the number of receptors in a synaptic terminal.

Synaptic adhesion molecules glue the per- and postsynaptic membranes together. This class of molecules is important during all phases of the life on a synapse. Initially, synaptic adhesion molecules allow the small protrusion of dendrites to contact axons. In the next step, the adhesive action of these molecules helps to stabilizing these contacts. Furthermore, synaptic adhesion molecules are signaling inside the axon or dendrite to recruit other molecules and thereby are important mediators for synapse development. Later synaptic adhesion molecules stabilize the synaptic complex.

 

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