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Seifollah Ahmadi

Seifollah Ahmadi6

Research focus - Synaptic transmission in the pain pathway

Our lboratory is particularly interested in the molecular and cellular basis of neutonal pain processing in the CNS. The neutronal network within the spinal horn of the spinal cord is an important guiding structure associated with chronic pain due to inflammation or nerve lesions. In fact, it is the first site of synaptic integration into the pain pathway.

We investigate isolated tissue preparations (cell culture and tissue section patches) of the back horn of rats and meows. We use different methods such as patch clamp technique, Ca2+ imaging and tweo-photon laser scanning microscopy.

Our current research focuses on the cellular and molecular effects and function of different neuropeptides (Nociceotin/Orphanin FQ, Nocistatin NST) and Prosta glands as important mediators in the synaptic processing of pain-related Signals within the spinal cord spinal horn.

In our recent studies, we have found that the central component of inflammatory pain stems from a disinhibition of dorsal horn neurons in which glycinigenic neurotransmission is inhibited by the inflammatory mediator prostaglandin e receptors of subtype EP2 and leads to protein kinase A (PKA)-dependent phosphorylation and finally to inhibition of postsynaptic glycine receptors containung subunit aplah-3 (GLR.a3).

 

Publications

Erleichterung der spinalen NMDA-Rezeptrströme durch synaptisch freigesetztes Glycin. Ahmadi, S; Muth-Selbach, U; Lauterbach, A; Lipfert, P; Neuhuber, WL; Zeilhofer HU (2003). Wissenschaft 300, 2094-209

PGE2 blockiert selektiv die hemmende glycinerge Neurotransmission auf oberflächliche dorsale Hornneuronen der Ratte. Ahmadi, S; Lippross,S; Neuhuber, WL; Zeilhofer HU (2002). Nat Neurosci 5, 34-40

Selektive Unterdrückung der hemmenden synaptischen Übertragung durch Nocistatin im Rückenmark der Ratte. Zeilhofer HU; Muth-Selbach, U; Gühring, H; Erb, K; Ahmadi, S (2000). J Neurosci 20, 4922-2929

GlyR a3: Ein wesentliches Ziel für die Sensibilisierung der Rückenmarksentzündung. Harvey, RJ; Depner, UB; Wässle, H; Ahmadi, S; Heindl,C; Reinold, H; Smart, TG; Harvey, K; Schütz, B; Abo-Salem, OM; Zimmer, A; Poisbeau, P; Welzl, H; wolfer, DP; Betz, H; Zeilhofer, HU; Müller, U (2004). Wissenschaft 304, 884-887

Die AMPA-Rezeptor-Untereinheiten GluR-A und GluR-B modulieren wechselseitig die synaptische Plastizität der Wirbelsäule und entzündliche Schmerzen. Hartmann, B; Ahmadi, S; Heppenstall, PA; Lewin, G; Schott, C; Borchardt, T; Seeburg, PH; Zeilhofer; HU; Sprengel, R; Kuner, R (2004). Neuron 44:637-650

Die spinale entzündliche Hyperalgesie wird durch PÜrostaglandin-E-Rezeptoren des Subtyps EP2 vermittelt. Reinold, H; Ahmadi, S; Depner, UB; Layh, B; Heindl, C; Hamza, M; Paahl, A; Brune, K; Narumiya, S; Muller, U; Zeilhofer, HU (2005). J Clin Invest.; 115(3):673-9

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