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Michael Hans

Hans1

Research focus

Our main goal is to understand the molecular function of membrane proteins in the context of their physiological and pathophysiological role.

Synapses mediate communication between the cells of the nervous system. Our laboratory deals with aspects of neuronal signal transduction mechanisms, i.e. how synaptic receptors and ion channels are involves in communication between neurons or from nerve to muscle. A major goal of the laboratory is to understand the molecular events that make up agonist binding, receptor and receptor.
Activation and ion permeation through membrane channels. We are currently focusing in several aspects of signal transduction mediated by neuronal Ca2+ channels and nicotinic acid containing acteylcholine receptors (nAChR). For the investigation of neuronal communication on cellular and multicellular level we use in vitro preparations (acutely isolated neurons, brain slices). The applied technieques are patch clamp (electrophysiology) and optical methods like IR-DIC, ion sensitive color formation wit cooled CCD cameras and multi-photon laser scanning microscopy.

Some specific topics currently under investigation:

- Structure-funkctionrelationship according to nAChR
- nAChR e Subunit mutations associated with congenital myastic syndrome
- Ca2+ channels and nAChR in somatosensory neurons and their modulation by nicotine-related substances
- Modulation of the ignition activity of fopaminergic neurons

 

Publications

Gliazellen werden mit Synapsen geboren. Kukley, M; Kiladze, M; Tognatta, R; Hans, M; Swandulla, D; Schramm, J; Dietrich, D (2008). FASEB Journal, in der Presse

Modulation spannungsabhängiger Natriumkanäle durch den Delta-Agonisten SNC80 in akut isolierten Hippokampusneuronen der Ratte. Remx, C; Remy, S; Beck, H; Swandulla, D; Hans, M (2004). Neuropharmakologie 47, 1102-1112

Hyperpolarisierende Hemmung entwickelt sich ihne trophische Unterstützung durch GABA in kultivierten Ratten-Mittelhirnnerven. Titz, S; Hans, M; Kelsch, W; Lewen, A; Swandulla, D; Misgeld, U (2003). J Physiol 550:719-730

Strukturelemente in Domäne IV, die die biophysikalischen und pharmakologischen Eigenschaften des Menschen beeinflussen a1a enthaltende hochspannungsaktivierte Kalziumkanäle. Hans, M; Urrutia, A; Deal, C; Brust PF; Stauderman, K; Ellis, SB; Harpold, MM; Johnsin EC; Williiams, ME (1999). Biophys J 76:1384-1400

Funktionale Folgen von Mutationen in der menschlichen a1a Kalziumkanal-Untereinheit im Zusammenhang mit familiärer hemiolegischer Migräne. Hans, M; Luvisetto,S; Williams, ME; Spagnolo, M; Urrutia, A; Tottene, A; Brust, PF; Johnson, EC; Harpold, MM; Stauderman, KA; Pietrobon, D (1999). J Neurowissenschaft 19:1610-1619

Struktur und funktionelle Charakterisierung eines neuartigen menschlichen niederspannungsaktivierten Kalziumkanals. Williams, ME; Washburn, MS; Hans, M; Urrutia, A; Brust, PF; Prodanovich, P; Harpold, MM; Staudermann, KA (1999). J Neurochem 72:791-799

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